Hydrochloric Acid → 4-Nitrophenol

HRID 1009842Notes

Reaction equation

HRID 1009842 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].NC(N)=S.C[O:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1.Cl>>[OH:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 74854-NitroanisoleHCID 2723790ThioureaHCID 6451240Aluminum(III) Chloride

Product 1

HCID 9804-NitrophenolYield 81.2%

Conditions

Temperature
40 °C

Procedure

To a mixture of 5.32 g (40 mmol) of aluminium chloride and 1.52 g (20 mmol) of thiourea 1.53 g (10 mmol) of 1-methoxy-4-nitrobenzene is added. The reaction mixture is heated to 40° C. and maintained at this temperature of 2 hours, then cooled to room temperature and 20 ml of 5 wt % hydrochloric acid is added. The precipitated product is filtered, washed and dried giving 1.13 g (81.2%) of 1-hydroxy-4-nitrobenzene.

Workup

  1. additionis added
  2. temperaturemaintained at this temperature of 2 hours
  3. temperaturecooled to room temperature
  4. filtrationThe precipitated product is filtered
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-c6c6f19559d6413282643f380af2bf7f
Source dataset
uspto-grants-2011_07
Patent number
US07973185B2

Reaction notes

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