HRID1009930

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID853605

4-{[(tert-Butoxycarbonyl)amino]methyl}benzoic acid

C13H17NO4

结构：COC[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CCN2C(=O)[C@H]1CCCC[C@H]1N.Cl.Cl

HCID67150533

未命名化合物

PRODUCTS

生成物

结构：COC[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CCN2C(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(CNC(=O)OC(C)(C)C)cc1

HCID57846897

未命名化合物

PROCEDURE

实验过程

In the same manner as in Reference Example 19 and using 4-{[(tert-butoxycarbonyl)amino]methyl}benzoic acid and (1R,2S)-2-{[(3aR,4R,9bR)-4-(methoxymethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexaneamine dihydrochloride, the title compound was synthesized.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67edc4d982154a1eacf1370a6322c4cf
来源数据集: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07973163B2
来源说明: uspto-grants-2011_07

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[CH3:21][O:22][CH2:23][C@H:24]1[C@H:33]2[CH2:34][CH2:35][N:36]([C:37]([C@H:39]3[CH2:44][CH2:43][CH2:42][CH2:41][C@H:40]3[NH2:45])=[O:38])[C@H:32]2[C:31]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[NH:25]1>>[CH3:21][O:22][CH2:23][C@H:24]1[C@H:33]2[CH2:34][CH2:35][N:36]([C:37]([C@H:39]3[CH2:44][CH2:43][CH2:42][CH2:41][C@H:40]3[NH:45][C:14]([C:13]3[CH:12]=[CH:11][C:10]([CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[CH:18][CH:17]=3)=[O:16])=[O:38])[C@H:32]2[C:31]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[NH:25]1