Hydrochloric Acid → HCID 22936545, compound

HRID 1010143Notes

Reaction equation

HRID 1010143 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:24])=[CH:18][CH:17]=1)#[N:2].[OH-:32].[Na+].Cl>CS(C)=O>[NH:25]([C:23]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][C:6]2[C:5]3[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([C:1]([NH2:2])=[O:32])[CH:4]=3)[N:9]=[CH:8][CH:7]=2)=[CH:21][CH:20]=1)=[O:24])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22936478HCID 22936478, compound

Product 1

HCID 22936545HCID 22936545, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The N-(4-(6-cyano-7-methoxy-4-quinolyl)oxyphenyl)-N′-phenylurea (100 mg) synthesized in Example 37 was dissolved in dimethylsulfoxide (3 ml) at 80° C., and then 5N aqueous sodium hydroxide was added and the mixture was heated and stirred for 2 hours. The reaction solution was neutralized with 1N hydrochloric acid, and the precipitated crystals were filtered out and washed with ethanol to obtain the title compound (60 mg).

Workup

  1. temperaturethe mixture was heated
  2. filtrationthe precipitated crystals were filtered out
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-5c13bed424c44457b88eb244346b4c6b
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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