Formic Acid → HCID 178518056, compound

HRID 1010148Notes

Reaction equation

HRID 1010148 reaction equation
C(O)=O.[CH:4]([NH2:6])=O.[NH2:7][C:8]1[NH:9][C:10]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:20][CH:19]=2)=[CH:11][C:12]=1[C:13](OCC)=[O:14]>CN(C)C=O>[CH2:25]([O:24][C:21]1[CH:22]=[CH:23][C:18]([C:10]2[NH:9][C:8]3[N:7]=[CH:4][N:6]=[C:13]([OH:14])[C:12]=3[CH:11]=2)=[CH:19][CH:20]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 713FormamideHCID 22936919ethyl 2-amino-5-(4-benzyloxyphenyl)-1H-pyrrole-3-carboxylate

Product 1

HCID 178518056HCID 178518056, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
140 °C

Procedure

After adding 84 ml of formic acid, 338 ml of formamide and 169 ml of dimethylformamide to 56.7 g of the ethyl 2-amino-5-(4-benzyloxyphenyl)-1H-pyrrole-3-carboxylate synthesized in Production Example 153-1, the mixture was stirred at 140° C. for 48 hours and then allowed to stand at room temperature for 24 hours. The precipitated solid was filtered out and dried under reduced pressure to obtain 41 g of the title compound.

Workup

  1. customsynthesized in Production Example 153-1
  2. waitto stand at room temperature for 24 hours
  3. filtrationThe precipitated solid was filtered out
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-18605ded132346fe88e82b0f2a777247
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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