反应详情

Methyl 4-{3-chloro-4-[(phenoxycarbonyl)amino]phenoxy}-7-(2-methoxyethoxy)-6-quinolinecarboxylate (3.2 g), cyclopropylamine (1.3 ml) and dimethylformamide (20 ml) were stirred together at 60° C. for 10 minutes. The mixture was returned to room temperature, water was added, and extraction was performed with ethyl acetate. Silica gel was added to the extract solution and the solvent was distilled off under reduced pressure. The silica gel was charged into a dry column packed with silica gel, and purification was performed by column chromatography (ethyl acetate, followed by ethyl acetate:methanol=50:1, 20:1) to obtain 2.26 g of the target substance as a white powder.

1. customwas returned to room temperature
2. extractionextraction
3. additionSilica gel was added to the extract solution
4. distillationthe solvent was distilled off under reduced pressure
5. additionThe silica gel was charged into a dry column
6. custompacked with silica gel, and purification
7. customto obtain 2.26 g of the target substance as a white powder