Hydrochloric Acid → HCID 22936715, compound

HRID 1010301Notes

Reaction equation

HRID 1010301 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:37]=[CH:36][C:7]([NH:8][C:9]([N:11]([CH3:35])[C:12]2[CH:34]=[CH:33][C:15]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:31][CH3:32])=[C:24]([C:27]([O:29]C)=[O:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:6][CH:5]=1.Cl>CO>[F:3][C:4]1[CH:5]=[CH:6][C:7]([NH:8][C:9]([N:11]([CH3:35])[C:12]2[CH:34]=[CH:33][C:15]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:31][CH3:32])=[C:24]([C:27]([OH:29])=[O:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:14][CH:13]=2)=[O:10])=[CH:36][CH:37]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23069576HCID 23069576, compound

Product 1

HCID 22936715HCID 22936715, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After adding methanol (20 ml) and 2N aqueous sodium hydroxide (5 ml) to methyl 4-(4-(((4-fluoroanilino)carbonyl)(methyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxylate (1.042 g, 2.19 mmol), the mixture was stirred at room temperature for 3 hours. 2N Hydrochloric acid was added to the reaction solution for neutralization, and then the methanol was distilled off under reduced pressure and the precipitated white crystals were filtered out and dried at 70° C. to obtain the title compound (1.01 g, 2.19 mmol, quantitative).

Workup

  1. distillationthe methanol was distilled off under reduced pressure
  2. filtrationthe precipitated white crystals were filtered out
  3. customdried at 70° C.

Sources & evidence

ORD record
ord-1b866933027146e797bd22a2ff507ac8
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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