Hydrochloric Acid → HCID 58931088, compound

HRID 1010353Notes

Reaction equation

HRID 1010353 reaction equation
[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=4)=[O:22])=[CH:16][CH:15]=3)=[CH:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[O:31][CH3:32])#[N:2].[OH-:33].[Na+].Cl>CS(C)=O>[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][C:14]3[CH:15]=[CH:16][C:17]([NH:20][C:21]([NH:23][C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=4)=[O:22])=[CH:18][CH:19]=3)=[CH:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[O:31][CH3:32])(=[O:33])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67204014N-(4-[(7-cyano-6-methoxy-4-quinolyl)oxy]phenyl)-N'-(4-fluorophenyl)urea

Product 1

HCID 58931088HCID 58931088, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

After dissolving N-(4-[(7-cyano-6-methoxy-4-quinolyl)oxy]phenyl)-N′-(4-fluorophenyl)urea (43 mg) in 1.5 ml of dimethylsulfoxide at 80° C., a 5N aqueous NaOH solution was added thereto and the mixture was heated and stirred for 2 hours. The reaction solution was neutralized with 1N HCl and the precipitated crystals were filtered out and washed with ethanol to obtain 17 mg of the title compound.

Workup

  1. temperaturethe mixture was heated
  2. filtrationthe precipitated crystals were filtered out
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-c6d43dd85aaa4b5abab9eba5994d707c
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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