Dimethyl Sulfoxide → HCID 86591475, compound

HRID 1010363Notes

Reaction equation

HRID 1010363 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.CS(C)=O.C1([O:15][C:16](=O)[NH:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH2:38][C@H:39]5[CH2:41][O:40]5)=[C:32]([C:35]#[N:36])[CH:33]=4)[N:28]=[CH:27][CH:26]=3)=[CH:20][C:19]=2[F:42])C=CC=CC=1.O>C(OCC)(=O)C>[F:42][C:19]1[CH:20]=[C:21]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:37][CH2:38][C@H:39]4[CH2:41][O:40]4)=[C:32]([C:35]#[N:36])[CH:33]=3)[N:28]=[CH:27][CH:26]=2)[CH:22]=[CH:23][C:18]=1[NH:17][C:16]([NH:4][CH:1]1[CH2:3][CH2:2]1)=[O:15]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 69828CyclopropylamineHCID 86591476HCID 86591476, compound

Product 1

HCID 86591475HCID 86591475, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Cyclopropylamine (0.04 ml) was added to dimethylsulfoxide (3 ml), and then [2-fluoro-4-([6-cyano-7-([(2R)-oxiran-2-yl]methoxy)-4-quinolyl]oxy)phenyl]carbamic acid phenyl ester (212 mg) was dissolved therein and the solution was stirred for 10 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (150 mg).

Workup

  1. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-517f5604f1c448c981331fc565533576
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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