Dimethyl Sulfoxide → HCID 22936456, compound

HRID 1010456Notes

Reaction equation

HRID 1010456 reaction equation
[CH2:1]([NH2:3])[CH3:2].CS(C)=O.C1([O:14][C:15](=O)[NH:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[C:33]4[C:28](=[CH:29][C:30]([O:37][CH3:38])=[C:31]([C:34](=[O:36])[NH2:35])[CH:32]=4)[N:27]=[CH:26][CH:25]=3)=[CH:19][C:18]=2[C:39]([F:42])([F:41])[F:40])C=CC=CC=1.O>C(OCC)(=O)C>[C:34]([C:31]1[CH:32]=[C:33]2[C:28](=[CH:29][C:30]=1[O:37][CH3:38])[N:27]=[CH:26][CH:25]=[C:24]2[O:23][C:20]1[CH:21]=[CH:22][C:17]([NH:16][C:15]([NH:3][CH2:1][CH3:2])=[O:14])=[C:18]([C:39]([F:41])([F:40])[F:42])[CH:19]=1)(=[O:36])[NH2:35]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6341EthylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936456HCID 22936456, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Ethylamine 2N tetrahydrofuran solution (0.10 ml) was added to dimethylsulfoxide (0.5 ml), and then (4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl)carbamic acid phenyl ester (25 mg) was dissolved therein and the mixture was stirred for 10 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (5.0 mg).

Workup

  1. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-a1dabc079a1141c591790e7207c06893
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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