Methylamine → HCID 22936664, compound

HRID 1010457Notes

Reaction equation

HRID 1010457 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[C:32]([F:35])([F:34])[F:33])C=CC=CC=1.[CH3:37][NH2:38]>>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:38][CH3:37])=[O:7])=[C:11]([C:32]([F:34])([F:33])[F:35])[CH:12]=1)(=[O:29])[NH2:28]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 67202368HCID 67202368, compound

Product 1

HCID 22936664HCID 22936664, compound

Procedure

After adding [4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-trifluoromethylphenyl]carbamic acid phenyl ester (25 mg) to methylamine 2N tetrahydrofuran solution (1.00 ml), the mixture was stirred for 10 minutes. The precipitated crystals were filtered out and washed with tetrahydrofuran to obtain the title compound (10 mg).

Workup

  1. filtrationThe precipitated crystals were filtered out
  2. washwashed with tetrahydrofuran

Sources & evidence

ORD record
ord-db3e01a8a6fc4d39bc3a1414a84948f2
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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