反应详情

温度

50 °C

To a stirring mixture of 4.36 g (38.0 mmol) of 2-chloroethylamine hydrochloride and 12.00 g (87.0 mmol) of K2CO3 in 30 mL of CHCl3 was added 4.82 g (29.0 mmol) of 4-t-butylbenzenethiol. The mixture was stirred at 50° C. in a sealed vial overnight. The mixture was washed three times with distilled water, dried with MgSO4 and filtered. Volatiles were removed in vacuo leaving 4.50 g (74%) of clear oil. 1H NMR (300 MHz, CDCl3): δ=7.32, m, 4H, 2.93, m, 4H, 1.42, broad singlet, 2H, 1.30, s, 9H.

1. washThe mixture was washed three times with distilled water
2. dry with materialdried with MgSO4
3. filtrationfiltered
4. customVolatiles were removed in vacuo