Ethyl cyanoacetate → 4-Methylbenzaldehyde

HRID 1010525Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:8])[CH2:5]C#[N:7])C.[CH:9]1([C:15](C)=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[C:4]([O-:8])(=[O:3])[CH3:5].[NH4+:7].[CH3:1][C:12]1[CH:11]=[CH:10][C:9]([CH:15]=[O:16])=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 7764Ethyl cyanoacetate

HCID 13207Cyclohexyl methyl ketone

Product 2

HCID 77254-Methylbenzaldehyde

HCID 517165Ammonium Acetate

Procedure

Analogously to Example 1a), 1.4 g of product is obtained from 5.13 g of ammonium acetate, 886 μl of cyanoacetic acid ethyl ester, 1.14 ml of cyclohexylmethyl ketone and 1 g of 4-methylbenzaldehyde.

Sources & evidence

ORD record: ord-5d411c3b5d52482aa78e872c81b09501
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07977325B2

Reaction notes

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