Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Acetopiperone | HCID 76622 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11630560 | HCID 11630560 | — |
Reaction Steps
100 g of ammonium acetate is added to a solution of 12 g of isobutyraldehyde, 26 g of 3,4-methylenedioxy-acetophenone and 18 g of cyanoacetic acid ethyl ester in 300 ml of ethanol, and it is then refluxed for six hours while being stirred (80-90° C.). After cooling, the precipitate is suctioned off, washed first with cold ethanol and then with water and dried in air. Yield 17 g, melting point 266-268° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977325B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-8eab84b01d9c4bb6ad2c0d198400aad3 |
|---|
| Source note | uspto-grants-2011_07 |
|---|
