Isobutyraldehyde → HCID 11630560, compound

HRID 1010535Notes

Reaction equation

HRID 1010535 reaction equation
C([O-])(=O)C.[NH4+:5].[CH:6](=O)[CH:7]([CH3:9])[CH3:8].[CH3:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]2[O:20][CH2:21][O:22][C:16]=2[CH:15]=1)=O.C(O[C:26](=[O:30])[CH2:27][C:28]#[N:29])C>C(O)C>[CH:7]([C:9]1[CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]3[O:20][CH2:21][O:22][C:16]=3[CH:15]=2)[NH:5][C:26](=[O:30])[C:27]=1[C:28]#[N:29])([CH3:8])[CH3:6]

Participants

6

Reactant 4

HCID 6561IsobutyraldehydeHCID 7764Ethyl cyanoacetateHCID 76622AcetopiperoneHCID 517165Ammonium Acetate

Product 1

HCID 11630560HCID 11630560, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

100 g of ammonium acetate is added to a solution of 12 g of isobutyraldehyde, 26 g of 3,4-methylenedioxy-acetophenone and 18 g of cyanoacetic acid ethyl ester in 300 ml of ethanol, and it is then refluxed for six hours while being stirred (80-90° C.). After cooling, the precipitate is suctioned off, washed first with cold ethanol and then with water and dried in air. Yield 17 g, melting point 266-268° C.

Workup

  1. temperatureis then refluxed for six hours
  2. temperatureAfter cooling
  3. washwashed first with cold ethanol
  4. dry with materialwith water and dried in air

Sources & evidence

ORD record
ord-8eab84b01d9c4bb6ad2c0d198400aad3
Source dataset
uspto-grants-2011_07
Patent number
US07977325B2

Reaction notes

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