HCID 23634414, compound → HCID 57813721, compound

HRID 1010677Notes

Reaction equation

HRID 1010677 reaction equation
C(NC([NH:6][C:7]1[S:8][C:9]2[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][C:13]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:12][C:10]=2[N:11]=1)=O)C>CN(C=O)C>[N:24]1[CH:25]=[CH:26][CH:27]=[C:22]([C:13]2[CH:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:9]3[S:8][C:7]([NH2:6])=[N:11][C:10]=3[CH:12]=2)[CH:23]=1

Participants

3

Reactant 1

HCID 23634414HCID 23634414, compound

Product 1

HCID 57813721HCID 57813721, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

1-Ethyl-3-(5-pyridin-3-yl-7-pyridin-2-yl-benzothiazol-2-yl)-urea (0.19 g, 0.53 mmol) in DMF (10 mL), was heated at 120° C. for 10 h in pressure vessel. After the completion of the reaction (TLC monitoring), DMF was distilled off, added water and extracted with ethyl acetate. The crude solid (0.14 g, 90%) was used as such for the next step.

Workup

  1. distillationwas distilled off
  2. additionadded water
  3. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-45c4b858fe8e49bdb79ef8621e66a4ec
Source dataset
uspto-grants-2011_07
Patent number
US07977340B2

Reaction notes

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