反应详情

温度

65 °C

To an ice-cold solution of 1-benzoyl-3-(3-benzyloxy-5-bromo-phenyl)-thiourea (33.0 g, 74.70 mmol) in THF (500.0 mL) was added a solution of NaOH (15.0 g, 375.0 mmol) in H2O (180.0 mL). The resulting reaction mixture was stirred at 65° C. for 15 h. The reaction mass was then cooled to room temperature, added water and extracted with EtOAc (3×1.0 L). The combined organics was washed with water, dried over anhydrous Na2SO4 and concentrated under reduced pressure to get the desired compound (23.50 g, 94%) that was carried forward to the next step without further purification.

1. customThe resulting reaction mixture
2. temperatureThe reaction mass was then cooled to room temperature
3. extractionextracted with EtOAc (3×1.0 L)
4. washThe combined organics was washed with water
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated under reduced pressure