Hydrochloric Acid → Hydrochloric Acid

HRID 1010709Notes

Reaction equation

HRID 1010709 reaction equation
C[O:2][C:3](=[O:20])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:19]3[CH:18]=[CH:17][N:16]=[CH:15][C:14]=3[N:13]=[CH:12]2)=[CH:7][CH:6]=1.[ClH:21]>>[N:11]1([C:8]2[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:20])=[O:2])=[CH:10][CH:9]=2)[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[CH:12]1.[ClH:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67021375HCID 67021375, compound

Product 2

HCID 313Hydrochloric AcidHCID 67021528HCID 67021528, compound

Procedure

A mixture of 0.349 g of (4-imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid methyl ester and 3.5 ml of an 6 N aqueous solution of HCl is stirred and refluxed for 3 hours. The mixture obtained is allowed to cool to rt and is concentrated in vacuo. (4-Imidazo[4,5-c]pyridin-1-yl-phenyl)-acetic acid in the form of a hydrochloric acid salt is obtained: ES-MS: 254.0 [M+H]+; single peak at tR=1.20 min (System 1).

Workup

  1. temperaturerefluxed for 3 hours
  2. customThe mixture obtained
  3. concentrationis concentrated in vacuo

Sources & evidence

ORD record
ord-0a3663bf9aa94e0295a1e3bf9b7644a7
Source dataset
uspto-grants-2011_07
Patent number
US07977338B2

Reaction notes

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