4-Aminophenylacetic acid → HCID 67021355, compound

HRID 1010711Notes

Reaction equation

HRID 1010711 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([OH:21])=[O:20])=[CH:14][CH:13]=1.CO.O1CCOC[CH2:25]1>>[CH3:25][O:20][C:19](=[O:21])[CH2:18][C:15]1[CH:14]=[CH:13][C:12]([NH:11][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 145334-Aminophenylacetic acidHCID 27357814-Chloro-3-nitropyridineHCID 21966525Dioxane Methanol

Product 1

HCID 67021355HCID 67021355, compound

Procedure

A mixture of 0.500 g of 4-chloro-3-nitro-pyridine (LANCASTER) and 0.467 g of (4-amino-phenyl)-acetic acid (Aldrich) in 10 ml of MeOH/dioxane (1/1 v/v) is stirred and refluxed for 6 hours. The mixture obtained is allowed to cool to rt and is concentrated in vacuo. Crude [4-(3-nitro-pyridin-4-ylamino)-phenyl]-acetic acid methyl ester is obtained.

Workup

  1. temperaturerefluxed for 6 hours
  2. customThe mixture obtained
  3. concentrationis concentrated in vacuo

Sources & evidence

ORD record
ord-2e8109990e08481c8bc7c5a690bb8b6d
Source dataset
uspto-grants-2011_07
Patent number
US07977338B2

Reaction notes

Loading…