4-Piperidinol, 1-methyl- → 1020662-91-2

HRID 1010730Notes

Reaction equation

HRID 1010730 reaction equation
CC1N=CN([C:7]2[CH:8]=[C:9]([NH2:17])[CH:10]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:12]=2)C=1.[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([OH:25])[CH2:21][CH2:20]1>>[CH3:18][N:19]1[CH2:24][CH2:23][CH:22]([O:25][C:7]2[CH:8]=[C:9]([NH2:17])[CH:10]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:12]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 660484-Piperidinol, 1-methyl-HCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Product 1

HCID 673159281020662-91-2

Procedure

for preparing the compound of examples 43 to 46 may be obtained analogously to a method as described in WO2004005281 for 3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenylamine, but using 1-methyl-piperidin-4-ol. ES-MS: 275.2 [M+H]+; tR=2.41 min

Workup

  1. custommay be obtained analogously to a method

Sources & evidence

ORD record
ord-6ef96c18687244ccba2e8ee03bb568b8
Source dataset
uspto-grants-2011_07
Patent number
US07977338B2

Reaction notes

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