10-(Phenylmethyl)-5,8-dioxa-10-azadispiro[2.0.4.3]undecane → 5,8-Dioxa-10-azadispiro[2.0.4.3]undecane

HRID 1010794Notes

Reaction equation

HRID 1010794 reaction equation
C([N:8]1[CH2:14][C:11]2([CH2:13][CH2:12]2)[C:10]2([O:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>CCO.[Pd]>[CH2:13]1[C:11]2([CH2:14][NH:8][CH2:9][C:10]32[O:15][CH2:16][CH2:17][O:18]3)[CH2:12]1

Participants

4

Reactant 1

HCID 994289510-(Phenylmethyl)-5,8-dioxa-10-azadispiro[2.0.4.3]undecane

Product 1

HCID 224172225,8-Dioxa-10-azadispiro[2.0.4.3]undecane

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10-benzyl-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane (A) (1.0 g, similar prepared according to JMC 37, 3344) was mixed with Pd—C (10%, 600 mg) in EtOH (40 ml) and hydrogenated under H2 at 50 psi for 5 hour. The reaction was filtered through Celite and evaporated to give 5,8-Dioxa-10-azadispiro[2.0.4.3]undecane (B).

Workup

  1. filtrationThe reaction was filtered through Celite
  2. customevaporated

Sources & evidence

ORD record
ord-2fc18880c14545e0bf97678e81301cd0
Source dataset
uspto-grants-2011_07
Patent number
US07977346B2

Reaction notes

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