Sodium borohydride → 5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

HRID 1010798Notes

Reaction equation

HRID 1010798 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][C:9](=[O:11])[C:6]2([CH2:8][CH2:7]2)[CH2:5]1.[BH4-].[Na+]>CO>[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][CH:9]([OH:11])[C:6]2([CH2:7][CH2:8]2)[CH2:5]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 167382835-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one

Product 1

HCID 167382855-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one (100 mg) was dissolved into Methanol (8 ml) and stirred at RT. NaBH4 (100 mg) was added to the reaction and stirred at RT for 30 minutes. The reaction was evaporated and purified by column chromatography to give title compound. Mass: (M+1), 158

Workup

  1. stirringstirred at RT for 30 minutes
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

Sources & evidence

ORD record
ord-0effb4b5009a43d2a870d2f4eaaaca35
Source dataset
uspto-grants-2011_07
Patent number
US07977346B2

Reaction notes

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