HCID 58865961, compound → HCID 136007996, compound

HRID 1010837Notes

Reaction equation

HRID 1010837 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([CH:18]=1)[C:7]([NH:9][N:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]([NH2:17])=[O:16])=O>[OH-].[NH4+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:19])=[C:6]([C:7]2[NH:17][C:15](=[O:16])[C:11]3=[CH:12][CH:13]=[CH:14][N:10]3[N:9]=2)[CH:18]=1

Participants

3

Reactant 1

HCID 58865961HCID 58865961, compound

Product 1

HCID 136007996HCID 136007996, compoundYield 48.1%

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

1-(5-Chloro-2-fluoro-benzoylamino)-1H-pyrrole-2-carboxylic acid amide (200 mg, 0.71 mmole) was dissolved in 5 ml of 28% ammonium hydroxide in a sealed tube and heated to 80° C. overnight. The solution was purged with nitrogen to remove excess ammonia, and acidified with 1M hydrochloric acid to pH 2. The product was isolated by filtration, washed with water and vacuum dried to give 90 mg product (yield: 48%).

Workup

  1. customThe solution was purged with nitrogen
  2. customto remove excess ammonia
  3. customThe product was isolated by filtration
  4. washwashed with water and vacuum
  5. customdried

Sources & evidence

ORD record
ord-586dd8c377b24dccaf8984a1f7e9cdba
Source dataset
uspto-grants-2011_07
Patent number
US07977342B2

Reaction notes

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