Trifluoroacetic acid → 2-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

HRID 1010949Notes

Reaction equation

HRID 1010949 reaction equation
[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[N:11]2C2CCCCO2)=[C:7]([NH2:22])[N:6]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>CO>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[NH:11]2)=[C:7]([NH2:22])[N:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576996322-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

Product 1

HCID 1784440732-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[(2,2-dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (323 mg) in dry MeOH (3.23 mL) was added TFA (0.323 mL) and the reaction was stirred at room temperature for 48 h. The reaction was concentrated in vacuo to give a yellow residue. The residue was triturated with Et2O and was filtered to give the title compound as an off-white solid (252 mg).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue
  3. customThe residue was triturated with Et2O
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-0cef73a619304326896e486b2f08b258
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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