Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pentylamine | HCID 8060 | — |
| Reactant | 2-Chloro-9-(tetrahydropyran-2-yl)adenine | HCID 12777819 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57699576 | HCID 57699576 | 93.5% |
Reaction Steps
To a solution of 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (500 mg) in dry ethylene glycol (2.3 mL) was added 1-pentylamine (689 mg). The solution was stirred at reflux (120° C.) overnight. The reaction was cooled, taken up in EtOAc (30 mL) and washed with water (2×20 mL). The organics were separated, dried over MgSO4, filtered and concentrated in vacuo to give the title compound as a viscous brown oil (561 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07977344B2 |
|---|
| Source dataset | uspto-grants-2011_07 |
|---|
| ORD ID | ord-650aad52defc40cca02fa679747e9a30 |
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| Source note | uspto-grants-2011_07 |
|---|
