Trifluoroacetic acid → HCID 178447009, compound

HRID 1010970Notes

Reaction equation

HRID 1010970 reaction equation
[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5].[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576997022-[(1-Methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

Product 1

HCID 178447009HCID 178447009, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[(1-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (313 mg) in dry MeOH (3.13 mL) was added TFA (0.313 mL) and the mixture was stirred at room temperature for 48 h. The reaction mixture was concentrated in vacuo to give a yellow residue which was triturated with Et2O and filtered to give the title compound as an off-white solid (218 mg).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O
  4. filtrationfiltered

Sources & evidence

ORD record
ord-5c8bbd0f9df4412bb9bcfeb4618ca128
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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