反应详情

A mixture of (2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl methanesulfonate (1.5 g) and anhydrous lithium bromide (2.72 g) in acetone (40 mL) was refluxed under nitrogen for 4 h. The reaction was allowed to cool and the solvent was evaporated. The residue was treated with saturated sodium bicarbonate solution and was extracted with DCM (×3). The combined organics were washed with dilute brine, dried by passing through a hydrophobic frit and evaporated to give the title compound as a brown oil (1.23 g).

1. temperaturewas refluxed under nitrogen for 4 h
2. temperatureto cool
3. customthe solvent was evaporated
4. additionThe residue was treated with saturated sodium bicarbonate solution
5. extractionwas extracted with DCM (×3)
6. washThe combined organics were washed with dilute brine
7. customdried
8. customevaporated