Trifluoroacetic acid → HCID 178467992, compound

Participants

Reaction Conditions

Reaction Steps

2-{[2-(Ethyloxy)ethyl]oxy}-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (4.78 g, 14.2 mmol) was dissolved in MeOH (30 ml) and TFA (7.5 ml) was added with stirring at 0° C. The mixture was left standing at room temperature for 1 day. A white solid was formed. The solid was filtered off and washed with ethyl acetate and dried in vacuo. This gave product (4 g, 80.5%).

Provenance & Evidence