Trifluoroacetic acid → HCID 178467992, compound

HRID 1011001Notes

Reaction equation

HRID 1011001 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH3:2].[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH2:1]([O:3][CH2:4][CH2:5][O:6][C:7]1[NH:8][C:9]([NH2:24])=[C:10]2[C:14]([N:15]=1)=[N:13][C:12]([O:22][CH3:23])=[N:11]2)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57699743HCID 57699743, compound

Product 1

HCID 178467992HCID 178467992, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

2-{[2-(Ethyloxy)ethyl]oxy}-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (4.78 g, 14.2 mmol) was dissolved in MeOH (30 ml) and TFA (7.5 ml) was added with stirring at 0° C. The mixture was left standing at room temperature for 1 day. A white solid was formed. The solid was filtered off and washed with ethyl acetate and dried in vacuo. This gave product (4 g, 80.5%).

Workup

  1. waitThe mixture was left
  2. customA white solid was formed
  3. filtrationThe solid was filtered off
  4. washwashed with ethyl acetate
  5. customdried in vacuo

Sources & evidence

ORD record
ord-f0e52502eef2406a8773a7f28c29599a
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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