反应详情

温度

85 °C

To a stirred solution of potassium t.butoxide (9.3 g, 82.8 mmol) in 1-methoxy-2-propanol (70 ml) was added 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7 g, 27.6 mmol). The mixture was heated to 80-90° C. for 4 h. Then most of the solvent was removed by evaporation under reduced pressure. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, concentrated to give a brown oil (7.2 g, 84.7%).

1. customThen most of the solvent was removed by evaporation under reduced pressure
2. customThe residue was partitioned between water and dichloromethane
3. customThe dichloromethane layer was separated
4. concentrationconcentrated