1-Methoxy-2-propanol → 2-{[1-Methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Participants

Role	Name	HCID	Charge
Reactant	1-Methoxy-2-propanol	HCID 7900	—
Reactant	Potassium	HCID 5462222	—
Reactant	Butan-1-olate	HCID 12476378	—
Reactant	2-Chloro-9-(tetrahydropyran-2-yl)adenine	HCID 12777819	—
Product	2-{[1-Methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine	HCID 57699634	84.7%

Reaction Conditions

Temperature	85 °C

Reaction Steps

To a stirred solution of potassium t.butoxide (9.3 g, 82.8 mmol) in 1-methoxy-2-propanol (70 ml) was added 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7 g, 27.6 mmol). The mixture was heated to 80-90° C. for 4 h. Then most of the solvent was removed by evaporation under reduced pressure. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, concentrated to give a brown oil (7.2 g, 84.7%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07977344B2
Source dataset	uspto-grants-2011_07
ORD ID	ord-547a010ad50648109fb63c2d1b1f8c4a
Source note	uspto-grants-2011_07