反应详情

Sodium (1.16 g, 50.5 mmol) was dissolved in methanol (40 ml) and 8-bromo-2-{[1-methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (6.5 g, 16.8 mmol) added with stirring. The mixture was heated to reflux for 2 h. The solvent was removed by evaporation. The residue was purified on a silica column using DCM: MeOH 150:1 as eluent. This gave product (4.7 g, 82.9%).

1. temperatureThe mixture was heated
2. temperatureto reflux for 2 h
3. customThe solvent was removed by evaporation
4. customThe residue was purified on a silica column