反应详情

温度

105 °C

2-Chloro-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (0.20 g) was added to a suspension of 2-methyl-1-propanol (2 mL) and sodium tert-butoxide (0.288 g). The mixture was heated in a microwave for 30 minutes at 105° C. The reaction mixture was washed with water after diluting with ethyl acetate (50 mL). The organic was separated and dried by passing through a hydrophobic frit before volatiles were stripped off under reduced pressure to give a pinkish solid. This material was triturated with diethyl ether and filtered to give the title compound as a pinkish solid (91.1 mg).

1. washThe reaction mixture was washed with water
2. additionafter diluting with ethyl acetate (50 mL)
3. customThe organic was separated
4. customdried
5. customto give a pinkish solid
6. customThis material was triturated with diethyl ether
7. filtrationfiltered