Trifluoroacetic acid → HCID 178493990, compound

Participants

Reaction Steps

2-[(Cyclohexylmethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (0.7132 g, crude) was dissolved in methanol (5 mL). To this solution was added neat trifluoroacetic acid (0.5 mL). The reaction mixture was stirred at ambient room temperature for 18 hours. The solvent was evaporated under reduced pressure and residue triturated with ethyl acetate (50 mL). The white resultant solid was filtered, washed using diethyl ether (10 mL) and then dried under suction. This gave clean title compound as a white solid (0.2799 g).

Provenance & Evidence