Trifluoroacetic acid → HCID 178493990, compound

HRID 1011020Notes

Reaction equation

HRID 1011020 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[N:17]=[C:16]3[C:12]([N:13]=[C:14]([O:24][CH3:25])[N:15]3C3CCCCO3)=[C:11]([NH2:26])[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>CO>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[CH:1]1([CH2:7][O:8][C:9]2[N:17]=[C:16]3[C:12]([N:13]=[C:14]([O:24][CH3:25])[NH:15]3)=[C:11]([NH2:26])[N:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57699814HCID 57699814, compound

Product 1

HCID 178493990HCID 178493990, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[(Cyclohexylmethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (0.7132 g, crude) was dissolved in methanol (5 mL). To this solution was added neat trifluoroacetic acid (0.5 mL). The reaction mixture was stirred at ambient room temperature for 18 hours. The solvent was evaporated under reduced pressure and residue triturated with ethyl acetate (50 mL). The white resultant solid was filtered, washed using diethyl ether (10 mL) and then dried under suction. This gave clean title compound as a white solid (0.2799 g).

Workup

  1. customThe solvent was evaporated under reduced pressure and residue
  2. customtriturated with ethyl acetate (50 mL)
  3. filtrationThe white resultant solid was filtered
  4. washwashed
  5. customdried under suction

Sources & evidence

ORD record
ord-17a90b235bf24e29a5f0add9e329e677
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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