Trifluoroacetic acid → HCID 178496185, compound

HRID 1011026Notes

Reaction equation

HRID 1011026 reaction equation
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH2:15][O:16][CH3:17])[N:6]=2.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>CO>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH2:15][O:16][CH3:17])[N:6]=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576997378-(Methoxy)-2-{[2-(methyloxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

Product 1

HCID 178496185HCID 178496185, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-(Methoxy)-2-{[2-(methyloxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.2032 g) was dissolved in methanol (10 mL) which was treated with neat trifluoroacetic acid (1 mL) and then stirred for 2 days. The reaction mixture was evaporated under reduced pressure and the resultant solid suspended in ethyl acetate (25 mL) before being filtered to give the title compound (1.1310 g) as a white solid.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. filtrationbefore being filtered

Sources & evidence

ORD record
ord-4f9c797829384fa8b60bc379a122109c
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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