Trifluoroacetic acid → HCID 178493992, compound

HRID 1011032Notes

Reaction equation

HRID 1011032 reaction equation
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>CO>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576998158-(Methoxy)-2-[(tetrahydro-2-furanylmethyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine

Product 1

HCID 178493992HCID 178493992, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-(Methoxy)-2-[(tetrahydro-2-furanyl methyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.1614 g) was dissolved in methanol (20 mL) and treated with neat trifluoroacetic acid (2 mL). The reaction mixture was stirred for 24 hours to give a white suspension. The reaction mixture was then evaporated to dryness under reduced pressure. The resultant white solid was suspended using ethyl acetate (10 mL) and then isolated by filtration, washing with ethyl acetate (2 mL). The solid was air-dried under suction and then dried further under vacuo at 50° C. This gave the title compound as a white solid (1.0602 g).

Workup

  1. customto give a white suspension
  2. customThe reaction mixture was then evaporated to dryness under reduced pressure
  3. customisolated by filtration
  4. washwashing with ethyl acetate (2 mL)
  5. customThe solid was air-dried under suction
  6. customdried further under vacuo at 50° C

Sources & evidence

ORD record
ord-70d691defeeb4f9895a0a8af6cace0e2
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

Loading…