反应详情

To methanol (120 ml) was added sodium (0.966 g). When the metal was dissolved, 8-bromo-2-({2-[(1-methylethyl)oxy]ethyl}oxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (5.69 g, 21.2 mmol) was added, heated to reflux and the solution stirred for 16 h, cooled to room temperature. The solvent was removed. Extracted with ethyl acetate after adding water, dried and concentrated to give the crude product which was purified through silica gel eluting with 2:1 ethyl acetate:petroleum ether to give the title compound (4.8 g).

1. dissolutionWhen the metal was dissolved
2. temperatureheated
3. temperatureto reflux
4. customThe solvent was removed
5. extractionExtracted with ethyl acetate
6. additionafter adding water
7. customdried
8. concentrationconcentrated
9. customto give the crude product which
10. customwas purified through silica gel eluting with 2:1 ethyl acetate