反应详情

To 2-({2-[(1-methylethyl)oxy]ethyl}oxy)-8-(methoxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (4.5 g, 14 mmol) in methanol (30 ml) was added trifluoroacetic acid (8 ml), stirred for 10 min and held at room temperature for 2 days. Filtered to give the crude product which was purified by preparative hplc (Gilson GX-281 instrument with YMC C18 5.0 um column (250×20 mm) eluting with water containing TFA (0.1%): acetonitrile 30-60%. This gave the title compound 2.1 g.

1. waitheld at room temperature for 2 days
2. filtrationFiltered
3. customto give the crude product which
4. customwas purified by preparative hplc (Gilson GX-281 instrument with YMC C18 5.0 um column (250×20 mm)
5. washeluting with water
6. additioncontaining TFA (0.1%)