Triethylamine → (Tetrahydrofuran-3-yl)methyl methanesulfonate

HRID 1011051노트

반응식

HRID 1011051 반응식
[O:1]1[CH2:5][CH2:4][C@@H:3]([CH2:6][OH:7])[CH2:2]1.ClC1N=C2C(N=CN2CC2CCOCC2)=C(Cl)N=1.C(N(CC)CC)C.[CH3:33][S:34](Cl)(=[O:36])=[O:35]>ClCCl>[CH3:33][S:34]([O:7][CH2:6][CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1)(=[O:36])=[O:35]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 40784875((3S)-oxolan-3-yl)methanolHCID 576997032,6-Dichloro-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine

생성물 1

HCID 22273010(Tetrahydrofuran-3-yl)methyl methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To (3S)-tetrahydro-3-furanylmethanol, Isomer 2 (1.4 g) in dry dichloromethane (40 ml) at 0° C. and under nitrogen, was added triethylamine (3.83 ml) followed by methanesulfonyl chloride (1.39 ml). The reaction was stirred at room temperature overnight. The orange solution was diluted with dichloromethane (50 ml) and washed with saturated aqueous sodium bicarbonate (20 ml). The organic layer was separated, dried through a hydrophobic frit and concentrated in vacuo to yield the title compound as an orange oil (2.6 g).

후처리

  1. washwashed with saturated aqueous sodium bicarbonate (20 ml)
  2. customThe organic layer was separated
  3. customdried through a hydrophobic frit
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0def901c17794d9ea04c6a765e5289bd
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977344B2

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