(3R)-3-(2-bromoethyl)oxolane → N2-Butyl-8-(methyloxy)-9-[2-[(3S)-tetrahydro-3-furanyl]ethyl}-9H-Purine-2,6-diamine

HRID 1011078Notes

Reaction equation

HRID 1011078 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([NH:12][C:13]1[NH:21][C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]=2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11].Br[CH2:26][CH2:27][C@H:28]1[CH2:32][CH2:31][O:30][CH2:29]1>>[CH2:8]([NH:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]2[CH2:26][CH2:27][C@H:28]2[CH2:32][CH2:31][O:30][CH2:29]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 52324315(3R)-3-(2-bromoethyl)oxolaneHCID 178448877HCID 178448877, compound

Product 1

HCID 57699685N2-Butyl-8-(methyloxy)-9-[2-[(3S)-tetrahydro-3-furanyl]ethyl}-9H-Purine-2,6-diamine

Procedure

Prepared similarly to Intermediate 215 from N2-butyl-8-(methyloxy)-3H-purine-2,6-diamine trifluoroacetate and (3R)-3-(2-Bromoethyl)tetrahydrofuran.

Sources & evidence

ORD record
ord-6ca57d8b32fe456ba7c779b31c3496a6
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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