(3R)-3-(2-bromoethyl)oxolane → 2-(Butyloxy)-8-(methyloxy)-9-[2-[(3S)-tetrahydro-3-furanyl]ethyl]-9H-purin-6-amine

HRID 1011091Notes

Reaction equation

HRID 1011091 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:12][C:13]1[NH:14][C:15]([NH2:24])=[C:16]2[C:20]([N:21]=1)=[N:19][C:18]([O:22][CH3:23])=[N:17]2)[CH2:9][CH2:10][CH3:11].Br[CH2:26][CH2:27][C@H:28]1[CH2:32][CH2:31][O:30][CH2:29]1>>[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]2[CH2:26][CH2:27][C@H:28]2[CH2:32][CH2:31][O:30][CH2:29]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 52324315(3R)-3-(2-bromoethyl)oxolaneHCID 178450357HCID 178450357, compound

Product 1

HCID 576998302-(Butyloxy)-8-(methyloxy)-9-[2-[(3S)-tetrahydro-3-furanyl]ethyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 215 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and (3R)-3-(2-bromoethyl)tetrahydrofuran.

Sources & evidence

ORD record
ord-dd5e72571b79429abe88bbbd7623b017
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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