2-(2-Bromoethyl)oxolane → 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2-furanyl)ethyl]-9H-purin-6-amine

HRID 1011131Notes

Reaction equation

HRID 1011131 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23][CH3:24])=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH:29]1[CH2:33][CH2:32][CH2:31][O:30]1>>[CH3:8][C@@H:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:23][CH3:24])[N:20]2[CH2:27][CH2:28][CH:29]2[CH2:33][CH2:32][CH2:31][O:30]2)=[C:16]([NH2:25])[N:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 536918712-(2-Bromoethyl)oxolaneHCID 178448284HCID 178448284, compound

Product 1

HCID 576997332-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2-furanyl)ethyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 290 from 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 2-(2-bromoethyl)tetrahydrofuran.

Sources & evidence

ORD record
ord-60ca91350443462298e53cbd7b30cb13
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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