HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Bromoethyl)oxane → 2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2H-Pyran-4-yl)ethyl]-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Bromoethyl)oxane | HCID 22637012 | — |
| Reactant | HCID 178448284 | HCID 178448284 | — |
| Product | 2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2H-Pyran-4-yl)ethyl]-9H-purin-6-amine | HCID 57699789 | — |
Reaction Steps
Prepared similarly to Intermediate 223 from 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 4-(2-bromoethyl)tetrahydro-2H-pyran but conducting the alkylation over 1 hour at 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977344B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-c9994be50a3f43cbab4317ab538a6f4f |
| Source note | uspto-grants-2011_07 |