4-(3-Bromopropyl)oxane → 2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[3-(tetrahydro-2H-pyran-4-yl)propyl]-9H-purin-6-amine

HRID 1011143Notes

Reaction equation

HRID 1011143 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23][CH3:24])=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[CH3:8][C@@H:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:23][CH3:24])[N:20]2[CH2:27][CH2:28][CH2:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[C:16]([NH2:25])[N:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 576997044-(3-Bromopropyl)oxaneHCID 178448284HCID 178448284, compound

Product 1

HCID 576996942-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[3-(tetrahydro-2H-pyran-4-yl)propyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 216 from 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 4-(3-bromopropyl)tetrahydro-2H-pyran.

Sources & evidence

ORD record
ord-8a87fe4f999342ff867074f017b9c7dd
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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