Hydrochloric Acid → HCID 25025162, compound

HRID 1011151Notes

Reaction equation

HRID 1011151 reaction equation
[CH2:1]([NH:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:22]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][O:17]2)=[C:8]([NH2:24])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO.O1CCOCC1>[NH2:24][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:22])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][O:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57699578N2-Butyl-8-methoxy-9-(tetrahydro-2H-pyran-2-ylmethyl)-9H-purine-2,6-diamine

Product 1

HCID 25025162HCID 25025162, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N2-butyl-8-methoxy-9-(tetrahydro-2H-pyran-2-ylmethyl)-9H-purine-2,6-diamine in dry methanol (5 ml) at room temperature and under nitrogen was added 4.0M hydrogen chloride in 1,4-dioxane (1.5 ml) in one go. The reaction was left to stir at room temperature overnight. The reaction was concentrated in vacuo and the product purified by MDAP. This afforded the title compound 6 mg (slower-running on MDAP).

Workup

  1. waitThe reaction was left
  2. concentrationThe reaction was concentrated in vacuo
  3. customthe product purified by MDAP

Sources & evidence

ORD record
ord-fd317cb5836f41908866c4e721f1de35
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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