反应详情

2-Butoxy-8-methoxy-9-[2-(tetrahydro-2H-pyran-3-yl)ethyl]-9H-purin-6-amine (108 mg) was dissolved in methanol (2 ml) and 4N hydrogen chloride in dioxan (1 ml) added. After 16 h the reaction mixture was stripped, quenched with water then saturated sodium hydrogen carbonate added, when a solid precipitated. This was filtered, washed with water and dried. The solid was treated with hot methanol and was filtered after allowing to cool to yield 66 mg of the title compound.

1. customquenched with water
2. additionsaturated sodium hydrogen carbonate added
3. customwhen a solid precipitated
4. filtrationThis was filtered
5. washwashed with water
6. customdried
7. additionThe solid was treated with hot methanol
8. filtrationwas filtered
9. temperatureto cool