Hydrochloric Acid → 6-Amino-2-butylamino-9-[2-(tetrahydro-2H-Pyran-3-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

HRID 1011161Notes

Reaction equation

HRID 1011161 reaction equation
[CH2:1]([NH:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][O:19][CH2:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO.O1CCOCC1>[NH2:25][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][O:19][CH2:18]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57699758N2-Butyl-8-methoxy-9-[2-(tetrahydro-2H-pyran-3-yl)ethyl]-9H-purine-2,6-diamine

Product 1

HCID 250253636-Amino-2-butylamino-9-[2-(tetrahydro-2H-Pyran-3-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

N2-Butyl-8-methoxy-9-[2-(tetrahydro-2H-pyran-3-yl)ethyl]-9H-purine-2,6-diamine (138 mg) was dissolved in methanol (2 ml) and 4N hydrogen chloride in dioxan (1 ml) added. After 4 h the reaction mixture was stripped, quenched with water then made basic with saturated sodium hydrogen carbonate. The resulting solid was filtered, washed and dried to give the title compound, yield 105 mg.

Workup

  1. customquenched with water
  2. filtrationThe resulting solid was filtered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-c0e2508af5a14f38a3cdbddffa513332
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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