Hydrochloric Acid → HCID 25025365, compound

HRID 1011163Notes

Reaction equation

HRID 1011163 reaction equation
C[O:2][C:3]1[N:4]([CH2:19][CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:6]=2.Cl.[OH-].[Na+]>CO.O1CCOCC1>[NH2:12][C:9]1[N:8]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:6]=[C:5]2[C:10]=1[NH:11][C:3](=[O:2])[N:4]2[CH2:19][CH:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57699757HCID 57699757, compound

Product 1

HCID 25025365HCID 25025365, compoundYield 70.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 8-methoxy-N2-pentyl-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purine-2,6-diamine (140 mg) in dry MeOH (15.7 mL) was added 4N HCl in 1,4-dioxane (2.65 mL). The reaction mixture was stirred at room temperature for 3 h and was then neutralised with 2M sodium hydroxide solution. The mixture was concentrated in vacuo and the residue was taken up into water (20 mL). The mixture was filtered under reduced pressure to give the title compound (95 mg) as an off-white solid.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. filtrationThe mixture was filtered under reduced pressure

Sources & evidence

ORD record
ord-1df1a58e717d427cb7d0b33c58be0f53
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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