Hydrochloric Acid → HCID 25025554, compound

Participants

Reaction Steps

To a solution of 2-[(2-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (41 mg) in dry MeOH (4.5 mL) was added 4N HCl in 1,4-dioxane (0.766 mL) and the reaction mixture was stirred at room temperature for 3 h. The reaction was neutralised with 2M sodium hydroxide solution and concentrated in vacuo. The resulting white residue was taken up in water (20 mL) and was filtered under reduced pressure to give the title compound as an off-white solid (20 mg).

Provenance & Evidence