Hydrochloric Acid → HCID 25025554, compound

HRID 1011165Notes

Reaction equation

HRID 1011165 reaction equation
[CH3:1][CH:2]([CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:21]C)[N:11]2[CH2:14][CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[C:7]([NH2:23])[N:6]=1.Cl.[OH-].[Na+]>CO.O1CCOCC1>[NH2:23][C:7]1[N:6]=[C:5]([O:4][CH2:3][CH:2]([CH3:1])[CH2:24][CH3:25])[N:13]=[C:12]2[C:8]=1[NH:9][C:10](=[O:21])[N:11]2[CH2:14][CH:15]1[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57699654HCID 57699654, compound

Product 1

HCID 25025554HCID 25025554, compoundYield 50.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-[(2-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (41 mg) in dry MeOH (4.5 mL) was added 4N HCl in 1,4-dioxane (0.766 mL) and the reaction mixture was stirred at room temperature for 3 h. The reaction was neutralised with 2M sodium hydroxide solution and concentrated in vacuo. The resulting white residue was taken up in water (20 mL) and was filtered under reduced pressure to give the title compound as an off-white solid (20 mg).

Workup

  1. concentrationconcentrated in vacuo
  2. filtrationwas filtered under reduced pressure

Sources & evidence

ORD record
ord-fb14d1a9804947d68be9bc08803aed0c
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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